PhysiologyDisease Models & MechanismsPeer-reviewed
Fixed-dose streptozotocin combined with high-fat diet induces a stable type 2 diabetes-like phenotype in C57BL/6J mice
Claes Fryklund, Christian Simonsson, Alexandra Hellberg…·Maria Swanberg
This study shows that fixed-dose streptozotocin in HFD-fed mice induces a stable T2D-like phenotype, contrasting with weight-adjusted dosing which causes variability.
DOI 10.1242/dmm.053071