This study shows that fixed-dose streptozotocin in HFD-fed mice induces a stable T2D-like phenotype, contrasting with weight-adjusted dosing which causes variability.

Disease Models & Mechanisms · Aug 6, 2026Peer-reviewedPhysiology

Genome-wide association study of REM sleep behavior disorder in Parkinson's disease

Yuri Ludwig Sosero, Karl Heilbron, Pierre Fontanillas, Lucy Norcliffe‐Kaufmann, Eric Yu, Uladzislau Rudakou, Jennifer A. Ruskey, Kathryn Freeman, Farnaz Asayesh, Kajsa Atterling Brolin, Maria Swanberg, Huw R. Morris, Lesley Wu, Raquel Real, Lasse Pihlstrøm, , Ziv Gan‐Or

This study identifies genetic variants associated with REM sleep behavior disorder in Parkinson's disease and explores genetic correlations with neuropsychiatric traits.

npj Parkinson s Disease · Sep 25, 2025Peer-reviewedGenetic & Genomic Medicine

Lack of neuroprotection after systemic administration of the soluble TNF inhibitor XPro1595 in an rAAV6-α-Syn+PFFs-induced rat model for Parkinson's disease

Filip Fredlund, Claes Fryklund, Olivia Trujeque-Ramos, Hannah A. Staley, Joaquín Pardo, Kelvin C. Luk, Malú G. Tansey, Maria Swanberg

This study shows that systemic XPro1595, a TNF inhibitor, does not protect against -Syn-induced Parkinson's-like pathology in rats, despite being effective in other neurodegeneration models.

Neurobiology of Disease · Feb 13, 2025Peer-reviewedNeuroscience

Nigral Transcriptomic Profiles in Engrailed-1 Hemizygous Mouse Models of Parkinson's Disease Reveal Upregulation of Oxidative Phosphorylation-Related Genes Associated with Resistance to Dopaminergic Neurodegeneration

Lautaro F. Belfiori-Carrasco, Alfredo Dueñas Rey, Dorottya Mária Ralbovszki, Itzia Jiménez-Ferrer, Filip Bäckström, Sagar Shivayogi Balikai, Dag Ahrén, Kajsa Atterling Brolin, Maria Swanberg

This paper compares transcriptomic profiles in En1-hemizygous mice to identify gene expression differences linked to susceptibility to Parkinson's-like neurodegeneration.

bioRxiv · Mar 22, 2023 · PreprintGenetics

MHC class II transactivator effects on local and systemic immune responses in an α-synuclein seeded rat model for Parkinson's disease

Filip Fredlund, Itzia Jiménez-Ferrer, Kathleen Grabert, Lautaro F. Belfiori-Carrasco, Kelvin C. Luk, Maria Swanberg

This study examines how reduced Ciita levels affect immune responses in a rat model of Parkinson's disease, finding increased TNF levels and altered MHCII expression in immune cells.

bioRxiv · Dec 2, 2022 · PreprintNeuroscience

RIC3 variants are not associated with Parkinson's Disease in large European, Latin American, or East Asian cohorts

Kajsa Atterling Brolin, Sara Bandrés‐Ciga, Hampton L. Leonard, Mary B. Makarious, Cornelis Blauwendraat, Ignacio Fernandez Mata, Jia Nee Foo, Lasse Pihlstrøm, Maria Swanberg, Ziv Gan‐Or, Manuela M. X. Tan

The paper investigates RIC3 variants' association with Parkinson's Disease in multiple cohorts and finds no significant association.

Neurobiology of Aging · Sep 17, 2021Peer-reviewedGenetic & Genomic Medicine

Galectin-3, A Novel Endogenous Trem2 Ligand, Regulates Inflammatory Response and Aβ Fibrilation in Alzheimer’s Disease

Antonio Boza‐Serrano, Rocío Ruiz, Raquel Maria Sanchez-Varo, Yiyi Yang, Juan García‐Revilla, Itzia Jiménez-Ferrer, Agnes Paulus, Malin Wennström, Anna Vilalta, David H. Allendorf, José Carlos Dávila, Christopher J.R. Dunning, John Stegmayr, Sebastián Jiménez, The Netherland Brain, , Tomas Deierborg

This study identifies galectin-3 as a novel endogenous TREM2 ligand that regulates microglial activation and Aβ fibrillation in Alzheimer’s disease.

bioRxiv · Dec 4, 2018 · PreprintNeuroscience