p53Y220C-BET-bifunctionals (tPRIMEs) drive p53Y220C-mutant cancer cells into apoptosis
Charlotte Kelley, Jae Young Ahn, Scott F. Rusin, Thibaut Imberdis, Kong Xiong, Taylor Bramhall, Florence F. Wagner, Alexandra Joseph, Joshua C. Murtie, Moses Moustakim, Alexandra B. Lantermann
This study develops p53Y220C-tPRIMEs, bifunctional molecules that induce ternary complexes with p53Y220C and BET proteins, leading to apoptosis and growth inhibition in p53 mutant cancer cells.
bioRxiv · Aug 13, 2025 · PreprintCancer Biology