Florence F. Wagner

This study discovers BRD3290, a GluA3-preferring AMPA receptor PAM, but finds it does not improve cognitive function in mice despite target engagement.

This study develops p53Y220C-tPRIMEs, bifunctional molecules that induce ternary complexes with p53Y220C and BET proteins, leading to apoptosis and growth inhibition in p53 mutant cancer cells.

This study identifies new PPM1D inhibitors using a drug discovery platform and shows their distinct biological effects compared to other DDR and p53 pathway modulators.

The paper identifies small molecule regulators of biological pathways by matching compound effects to known pathway phenotypes in public cell image data.

The paper analyzes missense variants in 1,330 disease genes using 3D protein structures to identify mutational hotspots and their functional impact.

This study shows that Shank3 loss disrupts homeostatic plasticity and circuit stability, which can be rescued by lithium, suggesting a therapeutic target for Shankopathies.