Autophagy-dependent gut-to-yolk biomass conversion generates visceral polymorbidity in aging C. elegans
Marina Ezcurra, Alexandre Benedetto, Thanet Sornda, Ann F. Gilliat, Catherine Au, Qifeng Zhang, Sophie van Schelt, Alexandra L. Petrache, Yila de la Guardia, Shoshana Bar-Nun, Eleanor Tyler, Michael J. Wakelam, David Gems
This study identifies autophagy-mediated gut-to-yolk biomass conversion as a cause of visceral pathologies and polymorbidity in aging C. elegans, and shows that inhibiting this process extends lifespan.
bioRxiv · Dec 15, 2017 · PreprintPhysiology