Monomeric TDP-43 binds GU-rich RNA via its NTD but only its oligomers block cryptic exon inclusion
Aurélie Zbinden, Izabela Smok, Flaminia Pellegrini, Alexandra Oertel, Antoine Cléry, Vera I. Wiersma, Wan-Ping Huang, Beatrice Gatta, Weijia Zhong, Yaozong Li, Michael Götze, Martina Peter, Niklas Bargenda, Marián Hruška-Plocháň, Amedeo Caflisch, , Magdalini Polymenidou
This study shows that the NTD of TDP-43 binds UG-rich RNA on monomers, while oligomerization is essential for repressing cryptic exons.
bioRxiv · Oct 5, 2026 · PreprintMolecular Biology