Author

Aurélie Zbinden

University of ZurichORCID 0000-0002-7785-2741Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander LeitneriD· 2 shared Frédéric H.‐T. AllainiD· 2 shared Izabela SmokiD· 2 shared Magdalini PolymenidouiD· 2 shared Alexandra Oertel· 1 shared Amedeo CaflischiD· 1 shared Antoine CléryiD· 1 shared Beatrice GattaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersBiophysics

Alexander LeitnerORCID

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2 papers

Recent·Most cited

A qualitative and quantitative framework for the characterization of protein-RNA interactions by cross-linking mass spectrometry (XL-MS)

Izabela Smok, Aurélie Zbinden, Johannes Osterroth, Jianning Jiang, Frédéric H.‐T. Allain, Jonathan Hall, Magdalini Polymenidou, Alexander Leitner

This paper introduces a XL-MS workflow combining DDA and PRM for quantitative characterization of protein-RNA interactions, applied to TDP-43 and FOX1 complexes.

bioRxiv · Oct 19, 2026 · PreprintBiophysics

Monomeric TDP-43 binds GU-rich RNA via its NTD but only its oligomers block cryptic exon inclusion

Aurélie Zbinden, Izabela Smok, Flaminia Pellegrini, Alexandra Oertel, Antoine Cléry, Vera I. Wiersma, Wan-Ping Huang, Beatrice Gatta, Weijia Zhong, Yaozong Li, Michael Götze, Martina Peter, Niklas Bargenda, Marián Hruška-Plocháň, Amedeo Caflisch, , Magdalini Polymenidou

This study shows that the NTD of TDP-43 binds UG-rich RNA on monomers, while oligomerization is essential for repressing cryptic exons.

bioRxiv · Oct 5, 2026 · PreprintMolecular Biology