TLR4 signaling in neurons enhances calcium-permeable AMPAR currents and drives post-traumatic epileptogenesis
Akshata A. Korgaonkar, Ying Li, Dipika Sekhar, Deepak Subramanian, Jenieve Guevarra, Bogumila Swietek, Alexandra Pallottie, Sukwinder Singh, Kruthi Kella, Stella Elkabes, Vijayalakshmi Santhakumar
This study shows that TLR4 signaling in neurons increases calcium-permeable AMPAR currents and promotes post-traumatic epileptogenesis, with early blockade reducing seizure susceptibility.
Annals of Neurology · Feb 7, 2020Peer-reviewedNeuroscience