Vijayalakshmi Santhakumar

This study uses human forebrain organoids to show that concussive injury affects neurogenesis and neuroimmune signaling differently depending on developmental stage.

This study examines how presynaptic GABAB receptor signaling affects DG network dynamics and inhibition after status epilepticus, finding persistent hyperexcitability and a homeostatic role for GABAB receptors in early recovery.

This study identifies a TLR4-MMP-9 signaling axis that drives early post-TBI dentate gyrus circuit dysfunction and behavioral deficits in rodents.

This study identifies altered intrinsic excitability and circuit connectivity in semilunar granule cells in a mouse epilepsy model, contributing to spatial navigation deficits.

This paper introduces passive neuromodulation as a method to suppress epileptic seizures by draining energy from neural circuits, showing its efficacy in computational models.

The paper identifies differences in glutamatergic inputs and dendritic spine density between Semilunar Granule Cells and Granule Cells in the dentate gyrus, suggesting functional diversity.

This study shows that disrupting Nrp2 in interneuron precursors leads to ASD-like behaviors and increased seizure risk in mice.

The paper investigates the role of semilunar granule cells in contextual memory formation and finds that their recruitment is based on intrinsic properties and correlated inputs rather than circuit-driven inhibition.

This study investigates changes in axo-axonic cells (AACs) in the dentate gyrus after status epilepticus, showing reduced synaptic inputs and altered firing properties that impair their inhibitory function.

This study shows that concussive brain injury impairs pattern separation in the dentate gyrus, affecting both cellular decorrelation of temporal inputs and behavioral discrimination of similar spatial locations.

This study shows that electrical coupling between parvalbumin basket cells decreases after experimental status epilepticus in rats, without affecting coupling coefficient.

The paper investigates the role of parvalbumin interneurons in synaptic inhibition of dentate granule cells and semilunar granule cells, finding differential feedback inhibition in these cell types.

This study shows that Nrp2 deficiency in mice reduces interneuron subtypes and inhibitory regulation in the hippocampus, leading to seizures and autism-like behaviors.

ExBoX uses Boolean exclusion logic to achieve specific gene expression in neurons by combining activating and inhibiting recombinases, demonstrated in vitro and in vivo.

This study examines how moderate concussive brain injury in adolescent rats affects GABA currents in dentate projection neurons over time, showing changes in granule cells but not semilunar granule cells.

The paper examines structural and inhibitory differences between semilunar granule cells (SGCs) and granule cells (GCs) across postnatal development to identify reliable classification features.

This paper identifies distinct cellular mechanisms by which TLR4 regulates network excitability and working memory after brain injury, showing TNF's role in mediating these effects.

This study shows that TLR4 signaling in neurons increases calcium-permeable AMPAR currents and promotes post-traumatic epileptogenesis, with early blockade reducing seizure susceptibility.