Deepak Subramanian

This study examines how presynaptic GABAB receptor signaling affects DG network dynamics and inhibition after status epilepticus, finding persistent hyperexcitability and a homeostatic role for GABAB receptors in early recovery.

This study identifies a TLR4-MMP-9 signaling axis that drives early post-TBI dentate gyrus circuit dysfunction and behavioral deficits in rodents.

This study shows that disrupting Nrp2 in interneuron precursors leads to ASD-like behaviors and increased seizure risk in mice.

This study shows that Nrp2 deficiency in mice reduces interneuron subtypes and inhibitory regulation in the hippocampus, leading to seizures and autism-like behaviors.

This paper identifies distinct cellular mechanisms by which TLR4 regulates network excitability and working memory after brain injury, showing TNF's role in mediating these effects.

This study shows that TLR4 signaling in neurons increases calcium-permeable AMPAR currents and promotes post-traumatic epileptogenesis, with early blockade reducing seizure susceptibility.