Alternative exon splicing reveals hidden mitochondrial targeting of PLIN3
Axel K.F. Aguettaz, Yoan Arribat, Alexandra Schmitt, Aminata Gerihanov, Jocelyn Fleurimont, Jean Daraspe, Vithusan Vijayatheva, Cassandra Tabasso, Sylviane Lagarrigue, Ernesto Picardi, Sarah Cohen, Christel Genoud, Francesca Amati
The paper identifies an alternative splicing event in PLIN3 that generates a mitochondrial-targeted transcript, PLIN3B, which is unstable and not detectable as endogenous protein.
bioRxiv · Feb 19, 2026 · PreprintCell Biology