Pro-Cognitive Effects of IgM Isotype Anti-NMDAR1 Autoantibodies in Mice
Jenna M. DeWit, Tina Tebyanian, Alexandra Unapanta, Melonie N. Vaughn, Susan B. Powell, Victoria B. Risbrough, Xianjin Zhou
This study shows that IgM anti-NMDAR1 autoantibodies improve cognitive functions like sensorimotor gating and fear extinction in mice, contrasting with IgG's negative effects.
bioRxiv · Apr 28, 2026 · PreprintNeuroscience