Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons
Shane J. F. Cronin, Weonjin Yu, Ashley Hale, Simon Licht‐Mayer, Mark J. Crabtree, Joanna A. Korecka, Evgenii O. Tretiakov, Marco Sealey‐Cardona, Máté Somlyay, Masahiro Onji, Meilin An, Jesse D. Fox, Bruna Lenfers Turnes, Carlos Gomez Diaz, Débora da Luz Scheffer, , Josef Martin Penninger
This study demonstrates that BH4 deficiency exacerbates PD-related stressors and that BH4 augmentation protects dopaminergic neurons in multiple models.
bioRxiv · May 8, 2023 · PreprintNeuroscience