Mark J. Crabtree

This study shows that DENV-2 NS1 disrupts lymphatic endothelial cell function, causing hyperpermeability and impaired lymphangiogenesis, contributing to severe dengue pathogenesis.

This study shows formate reduces ischemic injury in male hearts by increasing protein S-nitrosation and preserving BH4 levels through a NOS-dependent mechanism.

This study demonstrates that BH4 deficiency exacerbates PD-related stressors and that BH4 augmentation protects dopaminergic neurons in multiple models.