Bruna Lenfers Turnes

Preclinical validation of AAV9-TECPR2 gene therapy in a novel knock-in model of TECPR2-related disorder

This study develops a TECPR2 knock-in mouse model and shows that AAV9-mediated gene therapy improves mechanosensory function, gait, and startle responses in neonatal mice with TECPR2 deficiency.

Colitis-induced visceral pain recruits central neurotensin neurons that modulate colonic sensitivity

This study identifies neurotensin-expressing neurons in the parabrachial nucleus that modulate colonic sensitivity and pain in colitis, suggesting neurotensin as a therapeutic target.

A genetically defined injured C-fibre nociceptor associated with neuromasdrives chronic spontaneous neuropathic pain

The paper identifies a specific subtype of injured C-fibre nociceptors in neuromas that drive chronic spontaneous neuropathic pain in mice.

ARBEL: A Machine Learning Tool with Light-Based Image Analysis for Automatic Classification of 3D Pain Behaviors

ARBEL automatically classifies 3D pain behaviors in mice using light-based analysis and pose estimation, achieving high precision and enabling efficient drug screening.

Selective modification of ascending spinal outputs in acute and neuropathic pain states

The paper examines how spinal nociceptive output changes in acute and neuropathic pain states using calcium imaging.

Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons

This study demonstrates that BH4 deficiency exacerbates PD-related stressors and that BH4 augmentation protects dopaminergic neurons in multiple models.