Author

Alexandra Wyatt

Centre Hospitalier Universitaire Sainte-Justine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Genetics· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

Alexey V. PshezhetskyiD· 1 shared Gustavo Monteiro VianaiD· 1 shared Shuxian Fan· 1 shared TianMeng XuiD· 1 shared Xuefang PaniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperGenetics

Alexey V. PshezhetskyORCID

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1 paper

Recent·Most cited

Inhibition of cathepsin B blocks amyloidogenesis in the mouse models of neurological lysosomal diseases mucopolysaccharidosis type IIIC and sialidosis

Gustavo Monteiro Viana, Xuefang Pan, Shuxian Fan, TianMeng Xu, Alexandra Wyatt, Alexey V. Pshezhetsky

This study shows that inhibiting cathepsin B reduces amyloid deposits in mouse models of lysosomal diseases, suggesting it as a potential therapeutic target.

Molecular Therapy — Methods & Clinical Development · Feb 11, 2025Peer-reviewedGenetics