Author

TianMeng Xu

Centre Hospitalier Universitaire Sainte-JustineORCID 0000-0001-6862-4715Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Alexey V. PshezhetskyiD· 2 shared Xuefang PaniD· 2 shared Alexandra Wyatt· 1 shared Alexei GorelikiD· 1 shared Angelo PalmigianoiD· 1 shared Bénédicte AmilhoniD· 1 shared Bhushan NagariD· 1 shared Brian BiggeriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiochemistry

Alexey V. PshezhetskyORCID

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2 papers

Recent·Most cited

BiochemistryJournal of Clinical InvestigationPeer-reviewedJun 17, 2025

Secondary deficiency of neuraminidase 1 contributes to CNS pathology in neurological mucopolysaccharidoses via hypersialylation of brain glycoproteins

TianMeng Xu, Rachel Heon‐Roberts, Travis Moore…·Alexey V. Pshezhetsky

This study shows that reduced NEU1 activity in neurological MPS leads to hypersialylation of brain glycoproteins, contributing to CNS pathology through disrupted synaptogenesis and behavior.

5 citations

humanmouse

𝕏 PostBluesky

GeneticsMolecular Therapy — Methods & Clinical DevelopmentPeer-reviewedFeb 11, 2025

Inhibition of cathepsin B blocks amyloidogenesis in the mouse models of neurological lysosomal diseases mucopolysaccharidosis type IIIC and sialidosis

Gustavo Monteiro Viana, Xuefang Pan, Shuxian Fan…·Alexey V. Pshezhetsky

This study shows that inhibiting cathepsin B reduces amyloid deposits in mouse models of lysosomal diseases, suggesting it as a potential therapeutic target.

2 citations

mousebulk RNA-seq

𝕏 PostBluesky