Author

Gustavo Monteiro Viana

Centre Hospitalier Universitaire Sainte-JustineORCID 0000-0003-0473-9665Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1

Frequent Co-Authors

Alexey V. PshezhetskyiD· 2 shared Xuefang PaniD· 2 shared Alexandra Wyatt· 1 shared Behzad Nasseri· 1 shared Carlos Ramón MoralesiD· 1 shared Derek N. RobertsoniD· 1 shared Éric BonneiliD· 1 shared Erjun ZhangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersGenetics

Alexey V. PshezhetskyORCID

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2 papers

Recent·Most cited

GeneticsbioRxivPreprintFeb 24, 2026

Synthetic analogue of adrenocorticotropic hormone, ACTH(4-7)PGP delays neurological manifestations in diseases of mucopolysaccharidosis III spectrum by reducing neuroinflammation and rescuing neurotransmission, synaptogenesis, and axonal demyelination

Travis Mooree, Patricia Dubot, Gustavo Monteiro Viana…·Alexey V. Pshezhetsky

The paper tests a synthetic peptide ACTH(4-7)PGP in MPS III mouse models, showing it improves synaptic function, reduces neuroinflammation, and extends lifespan.

DOI 10.64898/2026.02.20.707013

mouseexperimental assay

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GeneticsMolecular Therapy — Methods & Clinical DevelopmentPeer-reviewedFeb 11, 2025

Inhibition of cathepsin B blocks amyloidogenesis in the mouse models of neurological lysosomal diseases mucopolysaccharidosis type IIIC and sialidosis

Gustavo Monteiro Viana, Xuefang Pan, Shuxian Fan…·Alexey V. Pshezhetsky

This study shows that inhibiting cathepsin B reduces amyloid deposits in mouse models of lysosomal diseases, suggesting it as a potential therapeutic target.

2 citations

mousebulk RNA-seq

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