Computation model predicts Rho GTPase function with the Plexin Transmembrane receptor GAP activity on Rap1b via dynamic allosteric changes
Nisha Bhattarai, Lindsay J. Morrison, Alexandre F. Gomes, Paul B. Savage, Amita Rani Sahoo, Matthias Buck
The paper uses molecular dynamics simulations to analyze conformational changes in Plexin-B1 bound to Rap1b, Rnd1, and Rac1, revealing differences in dynamics and interactions.
bioRxiv · Mar 13, 2025 · PreprintBiophysics