Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners
Katie Colbert Coate, Chunhua Dai, A. K. Singh, Jade E. Stanley, Brittney A. Covington, Amber M. Bradley, Favour O. Oladipupo, Yulong Gong, Scott Wisniewski, Katelyn Sellick, Erick Spears, Greg Poffenberger, Anna Marie R Schornack, Alexandria Bustabad, Tyler J. Rodgers, , E. Danielle Dean
This study shows that blocking glucagon signaling increases non-alpha cell proliferation in islets, dependent on SLC7A2 and mTORC1, across multiple species and models.
Molecular Metabolism · Oct 19, 2024Peer-reviewedCell Biology