Alvin C. Powers

This study shows that MAFB is essential for maintaining adult human α-cell identity and function, linking its downregulation to impaired glucagon secretion and mitochondrial dysfunction in diabetes.

The paper maps the morphological and functional maturation of human endocrine pancreas from birth to age 10 using pediatric tissue samples and imaging techniques.

In 299 islet preparations from donors without diabetes, endocrine cell composition, not donor demographics, tracked insulin secretion, and δ cell percentage rose with type 2 diabetes genetic risk.

This paper introduces a multimodal pipeline for spatiomolecular analysis of tissue samples, demonstrating its application in Alzheimer's disease and type 2 diabetes.

The paper identifies islet-specific DNA hypomethylated regions linked to T2D risk by integrating DNA methylation data with GWAS and EHR data.

The paper identifies an inflammatory phenotype in aging human alpha cells and shows calorie restriction reduces inflammation in mice.

This study shows that blocking glucagon signaling increases non-alpha cell proliferation in islets, dependent on SLC7A2 and mTORC1, across multiple species and models.

AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics data, showing improved performance over existing methods in diabetic tissue analysis.

This study shows that m6A methylation, regulated by METTL3, controls the innate immune response in β-cells during T1D onset by modulating OAS mRNA stability.

The paper identifies combinatorial transcription factor expression in human islet cells and shows it correlates with functional maturity and electrophysiological activity.

Multi-ethnic type 2 diabetes (T2D) meta-analysis of 228,499 cases and 1,178,783 controls finds 318 previously unreported loci, 804 expression-colocalized genes, and 13 SNP-by-T2D vascular-outcome interactions.