Author

Alexis Leroy

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Amal Al Kadi· 1 shared Carole FournieriD· 1 shared Christine Charrat· 1 shared David Rageot· 1 shared Evelyne Jouvin‐MarcheiD· 1 shared Fabrice P. NavarroiD· 1 shared François GhiringhelliiD· 1 shared Julien VollaireiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Amal Al Kadi

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1 paper

Recent·Most cited

Second generation of LNP based mRNA vaccine leads to a T-cell-inflamed tumor microenvironment favorable for improving PD-1/PD-L1 blocking therapy and long-term immunity in a cold tumor model

Carole Fournier, Marion Mercey-Ressejac, Valentin Dérangère, Amal Al Kadi, David Rageot, Christine Charrat, Alexis Leroy, Julien Vollaire, Véronique Josserand, Marie Escudé, Séverine Escaich, François Ghiringhelli, Thomas Decaens, Fabrice P. Navarro, Evelyne Jouvin‐Marche, Patrice Noël Marche

This study shows that second-generation LNPs (Lipidots(R)) enhance antitumor immunity by remodeling the tumor microenvironment and synergizing with PD-1/PD-L1 blockade to improve therapeutic outcomes in cold tumors.

EBioMedicine · Jan 9, 2025Peer-reviewedImmunology