Fabrice P. Navarro

This paper enhances the immunogenicity of the M2e peptide by conjugating it to nanostructured lipid carriers using click chemistry, leading to improved anti-M2e antibody responses in mice.

The paper tracks monocyte infiltration and phenotypic changes in a rat epilepsy model, showing they adopt a microglia-like phenotype and sustain low-grade inflammation during chronic epilepsy.

This study shows that second-generation LNPs (Lipidots(R)) enhance antitumor immunity by remodeling the tumor microenvironment and synergizing with PD-1/PD-L1 blockade to improve therapeutic outcomes in cold tumors.

The paper compares inflammation levels in the hippocampus of mTLE patients and rat models of epilepsy, finding lower chronic inflammation in patients compared to acute post-SE inflammation in rats.