Valentin Dérangère

Second generation of LNP based mRNA vaccine leads to a T-cell-inflamed tumor microenvironment favorable for improving PD-1/PD-L1 blocking therapy and long-term immunity in a cold tumor model

This study shows that second-generation LNPs (Lipidots(R)) enhance antitumor immunity by remodeling the tumor microenvironment and synergizing with PD-1/PD-L1 blockade to improve therapeutic outcomes in cold tumors.

Deep learning uncovers histological patterns of YAP1/TEAD activity related to disease aggressiveness in cancer patients.

This study uses deep learning to predict YAP1/TEAD activity from histology slides, linking histological patterns to disease aggressiveness in cancer patients.

A Deep Learning solution for triaging patient with cancer from their predicted mutational status using histopathological images

This paper develops a deep learning pipeline to predict mutation status from histopathological images in cancer patients, identifying clinically relevant genes like TP53 and proposing screening strategies.