Autism-associated ASPM variant causes macrocephaly and social-cognitive deficits in mice
Sarika Singh, Hyopil Kim, Alev Ecevitoglu, Renee Chasse, Alexis M Ludko, Basavaraju G. Sanganahalli, Vishaak Gangasandra, Sung Rye Park, Siu‐Pok Yee, James J. Grady, John D. Salamone, ROSLYN HOLLY FITCH, Timothy Spellman, Fahmeed Hyder, Byoung-Il Bae
This study shows that an autism-associated ASPM mutation causes macrocephaly and social-cognitive deficits in mice by altering the excitatory-inhibitory neuron ratio.
bioRxiv · Feb 17, 2025 · PreprintNeuroscience