Hyopil Kim

DART: A GUI Pipeline for Aligning Histological Brain Sections to 3D Atlases and Automating Laser Microdissection

DART automates aligning histological brain sections to 3D atlases and generates ROI contours for laser microdissection, improving precision and reproducibility in tissue sampling.

Cell type-specific barcoding reveals the single-cell projectional architecture of the mouse midbrain dopaminergic system

The paper introduces POINTseq, a method for cell type-specific single-cell projection mapping, and applies it to map 5,902 dopaminergic neurons, revealing over 25 connectomic cell types and stereotyped projection motifs.

MAPseq2: a sensitive and cost-effective barcoded connectomics method

MAPseq2 improves sensitivity and reduces cost for barcoded connectomics by enhancing the original MAPseq protocol.

Autism-associated ASPM variant causes macrocephaly and social-cognitive deficits in mice

This study shows that an autism-associated ASPM mutation causes macrocephaly and social-cognitive deficits in mice by altering the excitatory-inhibitory neuron ratio.

Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

The paper investigates brain pH and lactate levels in animal models of neuropsychiatric disorders, finding decreased pH and increased lactate levels as common features across multiple models.

Hippocampal engram networks for fear memory recruit new synapses and modify pre-existing synapses in vivo.

This study tracks synaptic changes in the hippocampus during fear memory formation and extinction, showing synaptogenesis and synapse modification between CA3 and CA1 engram cells.