Author

Alexis T. Akerele

Meharry Medical College

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:GWAS summary statistics· 2 Organism:human· 2 Approach:statistical model· 2 Approach:deep learning· 1

Frequent Co-Authors

Hannah M. SeagleiD· 2 shared Todd L. EdwardsiD· 2 shared Adam Phillip BressiD· 1 shared Christopher O. OtienoiD· 1 shared Digna R. Velez EdwardsiD· 1 shared Dipender GilliD· 1 shared Donald R. MilleriD· 1 shared Jacklyn N. HellwegeiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Hannah M. SeagleORCID

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Author profile →

2 papers

Recent·Most cited

TRACE: A FINE-TUNED BIOMEDICAL LANGUAGE MODEL FOR DIRECTIONALLY INFORMED DRUG REPURPOSING FROM TRANSCRIPTOME-WIDE ASSOCIATION STUDIES

Christopher O. Otieno, Hannah M. Seagle, Alexis T. Akerele, James Jaworski, Lindsay A. Guare, Shefali Setia-Verma, Digna R. Velez Edwards, Todd L. Edwards

TRACE uses a fine-tuned biomedical language model to identify drug-gene pairs from TWAS data, achieving high recovery rates in validation studies.

medRxiv · Aug 28, 2026 · PreprintGenetic & Genomic Medicine

Genomics-Informed Drug Repurposing Strategy Identifies Novel Therapeutic Targets for Metabolic Dysfunction-Associated Steatotic Liver Disease.

Hannah M. Seagle, Alexis T. Akerele, Joseph A. DeCorte, Jacklyn N. Hellwege, Joseph H. Breeyear, Jeewoo Kim, Michael G. Levin, Samuel Khodurksy, Adam Phillip Bress, Kyung Min Lee, Jens Meiler, Dipender Gill, Jennifer S. Lee, Kent R. Heberer, Donald R. Miller, , Marijana Vujković

The paper identifies 57 druggable targets for MASLD using genetic data and evaluates their therapeutic potential through Mendelian randomization and structural modeling.

medRxiv · Feb 18, 2025 · PreprintGenetic & Genomic Medicine