Jacklyn N. Hellwege

This study identifies 21 novel genetic loci associated with keloids through a multi-ancestry GWAS, highlighting integrin signaling and fibrosis pathways.

The paper identifies 57 druggable targets for MASLD using genetic data and evaluates their therapeutic potential through Mendelian randomization and structural modeling.

This study uses GWAS and eQTL data to identify genetic effects on PUFA levels in RBCs and plasma, finding shared variants and differences in gene expression impacts.

The paper identifies gene-gene interactions affecting blood traits and disease risk using variance QTL approaches in large human cohorts.

This study investigates the association between polygenic risk scores for blood pressure traits and preeclampsia, finding shared genetic architecture but no improvement in prediction models.

This paper develops a genome-wide polygenic score for chronic kidney disease that incorporates APOL1 risk genotypes and shows consistent performance across four major continental ancestries.

The paper maps genetic variants to cell types in the kidney to identify disease mechanisms and drug targets.

The paper examines how changes in genetic admixture over time affect heterozygosity and health outcomes in a southeastern U.S. population.