Author

Hannah M. Seagle

Vanderbilt UniversityORCID 0000-0002-3834-4357Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:GWAS summary statistics· 2 Organism:human· 2 Approach:statistical model· 2 Approach:deep learning· 1

Frequent Co-Authors

Alexis T. Akerele· 2 shared Todd L. EdwardsiD· 2 shared Adam Phillip BressiD· 1 shared Christopher O. OtienoiD· 1 shared Digna R. Velez EdwardsiD· 1 shared Dipender GilliD· 1 shared Donald R. MilleriD· 1 shared Jacklyn N. HellwegeiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Alexis T. Akerele

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2 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintAug 28, 2026

TRACE: A FINE-TUNED BIOMEDICAL LANGUAGE MODEL FOR DIRECTIONALLY INFORMED DRUG REPURPOSING FROM TRANSCRIPTOME-WIDE ASSOCIATION STUDIES

Christopher O. Otieno, Hannah M. Seagle, Alexis T. Akerele…·Todd L. Edwards

TRACE uses a fine-tuned biomedical language model to identify drug-gene pairs from TWAS data, achieving high recovery rates in validation studies.

DOI 10.64898/2026.08.25.26361263

humanGWAS summary statistics

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintFeb 18, 2025

Genomics-Informed Drug Repurposing Strategy Identifies Novel Therapeutic Targets for Metabolic Dysfunction-Associated Steatotic Liver Disease.

Hannah M. Seagle, Alexis T. Akerele, Joseph A. DeCorte…·Marijana Vujković

The paper identifies 57 druggable targets for MASLD using genetic data and evaluates their therapeutic potential through Mendelian randomization and structural modeling.

2 citations

humanGWAS summary statistics

𝕏 PostBluesky