Author

Alexis T. Clark

University of Virginia

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Physiology· 1

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Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

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Ira G. SchulmaniD· 1 shared Lillian Russo-SavageiD· 1 shared Luke A. Ashton· 1 shared Nicolas A. Amselle· 1 shared Niki Haghshenas· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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1 shared paperPhysiology

Ira G. SchulmanORCID

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1 paper

Recent·Most cited

A Novel Mutation in LXRalpha Uncovers a Role for Cholesterol Sensing in Limiting Metabolic Dysfunction-Associated Steatohepatitis (MASH).

Alexis T. Clark, Lillian Russo-Savage, Luke A. Ashton, Niki Haghshenas, Nicolas A. Amselle, Ira G. Schulman

This study shows that a mutation in LXRalpha impairs cholesterol sensing, leading to MASH-like liver disease despite low triglycerides, and that restoring LXR signaling can reverse the condition.

Nature Communications · Jan 28, 2025Peer-reviewedPhysiology