Author

Nicolas A. Amselle

University of Virginia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

Alexis T. Clark· 1 shared Apeksha N. AgarwaliD· 1 shared Divyaa SrinivasaniD· 1 shared Dong Min LeeiD· 1 shared Eva CoreyiD· 1 shared Huihui YeiD· 1 shared Ira G. SchulmaniD· 1 shared Ji-Hoon Jeong· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperPhysiology

Alexis T. Clark

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Author profile →

2 papers

Recent·Most cited

m6A-Driven Intratumoral Cholesterol Biosynthesis Fuels Castration-Resistant Prostate Cancer Progression

Jihoon Lee, Zhao Zhang, Juyeong Hong, Ji-Hoon Jeong, Huihui Ye, Divyaa Srinivasan, Lei Kang, Santosh Lamichhane, Nicolas A. Amselle, Kayode Abidemi John, Matthew T. Hinds, Apeksha N. Agarwal, Dong Min Lee, Songmi Han, Martine P. Roudier, , Kexin Xu

This study identifies a functional cooperation between nuclear pore complexes and m6A signaling that promotes castration-resistant prostate cancer by linking mRNA export to cholesterol biosynthesis and androgen production.

bioRxiv · Sep 28, 2026 · PreprintCancer Biology

A Novel Mutation in LXRalpha Uncovers a Role for Cholesterol Sensing in Limiting Metabolic Dysfunction-Associated Steatohepatitis (MASH).

Alexis T. Clark, Lillian Russo-Savage, Luke A. Ashton, Niki Haghshenas, Nicolas A. Amselle, Ira G. Schulman

This study shows that a mutation in LXRalpha impairs cholesterol sensing, leading to MASH-like liver disease despite low triglycerides, and that restoring LXR signaling can reverse the condition.

Nature Communications · Jan 28, 2025Peer-reviewedPhysiology