Nutrient stress activates Rab5b-mediated autophagy to remodel the synaptic proteome
Melina Overhoff, Lotte Ickert, Sebastian Marten, Andrew Hill, Frederik Tellkamp, Ali Chitsaz, Saskia L. Ludwig, Philipp Antczak, Felix Carlo Koehler, Roman‐Ulrich Müller, Marcus Krüger, Natalia L. Kononenko
The paper shows nutrient stress activates Rab5b-mediated autophagy at synapses, leading to proteome remodeling, distinct from mTORC1 inhibition effects.
Cell Reports · Jul 31, 2026Peer-reviewedNeuroscience