Lotte Ickert

The paper shows nutrient stress activates Rab5b-mediated autophagy at synapses, leading to proteome remodeling, distinct from mTORC1 inhibition effects.

This study determines the cryo-EM structure of p62 and visualizes its filament organization and calcium-rich lipid droplet cargo in cells under stalled autophagy.

This study shows that autophagy regulator ATG5 protects cerebellar Purkinje cells by maintaining glycolytic activity, preventing neurodegeneration through regulation of glucose transporter 2.

This study shows that autophagy regulates neuronal excitability by controlling cAMP/PKA signaling through the targeting of PKA inhibitory subunits to autophagosomes.