Author

Melina Overhoff

University of CologneORCID 0000-0002-4208-8632Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Natalia L. KononenkoiD· 4 shared Frederik TellkampiD· 2 shared Janine TutasiD· 2 shared Lotte IckertiD· 2 shared Marcus KrügeriD· 2 shared Marianna TolveiD· 2 shared Alex von KriegsheimiD· 1 shared Ali Chitsaz· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersNeuroscience

Natalia L. KononenkoORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ER-liquid condensate contacts sequester FAM134B/C and RhoA to govern cell morphology

Natalia Jiménez-Moreno, Arianna Karageorgiou, Katie Winnington-Ingram, Jimi C. Wills, Chinmayi Pednekar, Melina Overhoff, Katherine Paine, Matthew Pearson, Lukas Gerasimavicius, Ann P. Wheeler, Natalia L. Kononenko, Joseph A. Marsh, Paul Verkade, Alex von Kriegsheim, Jon D. Lane, Simon Wilkinson

The paper identifies ER-liquid condensates that sequester FAM134B/C and RhoA, affecting cell morphology and cancer invasion.

Molecular Cell · Aug 17, 2026Peer-reviewedCell Biology

Nutrient stress activates Rab5b-mediated autophagy to remodel the synaptic proteome

Melina Overhoff, Lotte Ickert, Sebastian Marten, Andrew Hill, Frederik Tellkamp, Ali Chitsaz, Saskia L. Ludwig, Philipp Antczak, Felix Carlo Koehler, Roman‐Ulrich Müller, Marcus Krüger, Natalia L. Kononenko

The paper shows nutrient stress activates Rab5b-mediated autophagy at synapses, leading to proteome remodeling, distinct from mTORC1 inhibition effects.

Cell Reports · Jul 31, 2026Peer-reviewedNeuroscience

Endocytic adaptor AP-2 maintains Purkinje cell function by balancing cerebellar parallel and climbing fiber synapses

Marianna Tolve, Janine Tutas, Ebru Ozer, Ines Klein, Anne Petzold, Veronika J. Fritz, Melina Overhoff, Quinn Silverman, Ellie Koletsou, Filip Liebsch, Günter Schwarz, Tatiana M. Korotkova, Silvana Valtcheva, Graziana Gatto, Natalia L. Kononenko

This study shows that AP-2 maintains Purkinje cell function by balancing synaptic inputs from parallel and climbing fibers, preventing degeneration and motor dysfunction.

Cell Reports · Feb 1, 2025Peer-reviewedNeuroscience

Autophagy regulates neuronal excitability by controlling cAMP/Protein Kinase A signaling

Melina Overhoff, Frederik Tellkamp, S. Hess, Janine Tutas, Marianna Tolve, Marcel Faerfers, Lotte Ickert, Milad Mohammadi, Elodie De Bruyckere, Emmanouela Kallergi, Andrea Delle Vedove, Vassiliki Nikoletopoulou, B. Wirth, Jörg Isensee, Tim B. Hucho, , Natalia L. Kononenko

This study shows that autophagy regulates neuronal excitability by controlling cAMP/PKA signaling through the targeting of PKA inhibitory subunits to autophagosomes.

bioRxiv · Feb 11, 2022 · PreprintNeuroscience