Marcus Krüger

Gut Microbiota Fuel Aging Induced by Mitochondrial Dysfunction

This study shows mitochondrial dysfunction accelerates aging by disrupting gut microbiota structure and inducing immune dysregulation and inflammation through metabolic reprogramming.

Combination of enhanced gene activation and cell death causes lethal inflammatory pulmonary fibrosis

The paper shows that enhanced gene activation in specific LUBAC mutants leads to cell death and lethal lung fibrosis, revealing gene activation as a root cause of inflammatory disease.

Nutrient stress activates Rab5b-mediated autophagy to remodel the synaptic proteome

The paper shows nutrient stress activates Rab5b-mediated autophagy at synapses, leading to proteome remodeling, distinct from mTORC1 inhibition effects.

miR-378a Controls Cardiomyocyte Metabolism and Angiogenic Signaling

This study investigates miR-378a's role in cardiomyocyte metabolism, mitochondrial function, and angiogenic signaling, showing its impact on cardiac performance and limited therapeutic benefit from overexpression.

Integrated data from R405W desmin knock-in mice highlight alterations of mitochondrial function, protein quality control, and myofibrillar structure in the initial stages of myofibrillar myopathy

This study uses R405W desmin knock-in mice to identify mitochondrial dysfunction, protein quality control issues, and myofibrillar structural changes in myofibrillar myopathy.

CAMK2D causes heart failure in RBM20 cardiomyopathy

This study identifies CAMK2D overactivation as the cause of heart failure in RBM20 cardiomyopathy and shows pharmacological inhibition can reverse cardiac dysfunction.

Differential regulation of the proteome and phosphosproteome along the dorso-ventral axis of the early Drosophila embryo

The paper investigates proteome and phosphoproteome changes along the dorso-ventral axis of Drosophila embryos, revealing differential regulation and functional roles of proteins and phosphorylation events.

Targeting of scavenger receptors Stabilin-1 and Stabilin-2 ameliorates atherosclerosis by a plasma proteome switch mediating monocyte/macrophage suppression

This study shows that targeting scavenger receptors Stabilin-1 and Stabilin-2 reduces atherosclerosis by altering the plasma proteome, which suppresses monocyte/macrophage activity.

Heterotypic Assembly Mechanism Regulates CHIP E3 Ligase Activity

The paper investigates how the CHN-1/UFD-2 complex enhances ubiquitin chain formation through dimerization and chaperone-mediated regulation of substrate ubiquitylation.

Single-dose ethanol intoxication causes acute and lasting neuronal changes in the brain

The paper identifies acute and lasting molecular, cellular, and behavioral changes in mice after single-dose ethanol intoxication using proteomics and imaging.

Autophagy regulates neuronal excitability by controlling cAMP/Protein Kinase A signaling

This study shows that autophagy regulates neuronal excitability by controlling cAMP/PKA signaling through the targeting of PKA inhibitory subunits to autophagosomes.

Nonsense-mediated mRNA decay relies on "two-factor authentication" by SMG5-SMG7

The paper reveals that SMG5-SMG7 and SMG6 work in a coordinated, hierarchical manner in NMD, with SMG5-SMG7 enabling SMG6 activity through UPF1 phosphorylation and heterodimer formation.

CASC3 promotes transcriptome-wide activation of nonsense-mediated decay by the exon junction complex

This study shows that CASC3 enhances NMD by linking the EJC to the NMD machinery, leading to increased degradation of NMD-targeted mRNAs.