Engineered α-Synuclein-specific nanobody CAR iTregs restrain neuroinflammation and proteinopathy in Parkinson's disease mice
Alice Calderoni, Melania Nannoni, Giorgia Ruffini, Matteo Doglio, Clara Bercher-Brayer, Serena Gea Giannelli, Ronald Melki, Monica Casucci, Chiara Bonini, Sharon Muggeo, Vania Broccoli
This study develops Syn-specific CAR iTregs that reduce neuroinflammation and proteinopathy in PD mice by selectively targeting aggregated α-Synuclein.
bioRxiv · Aug 22, 2026 · PreprintNeuroscience