Sharon Muggeo

This study develops Syn-specific CAR iTregs that reduce neuroinflammation and proteinopathy in PD mice by selectively targeting aggregated α-Synuclein.

This paper develops a fully human stem cell-derived BBB model to study disease mechanisms and evaluate neurotropic AAV capsids.

This paper develops AAV-STITCH, a method to target neuroblastoma cells using anti-GD2 ScFv coupled to AAV capsids, showing selective transduction and tumor suppression in mouse models.

This study identifies MCT1-dependent metabolic failure and neuroinflammation as key factors in optic nerve degeneration in Wolfram syndrome mice, suggesting therapeutic targets for early intervention.

This study investigates how loss of Scn1a affects CA1 pyramidal cell development and homeostatic plasticity in a Dravet Syndrome model before seizures occur.