Translation Attenuation by Minocycline Increases Lifespan and Improves Proteostasis in Old Post-Stress-Responsive Organisms
Gregory M. Solis, Rozina Kardakaris, Elizabeth R. Valentine, Liron Bar-Peled, Alice L. Chen, Megan M. Blewett, Mark A. McCormick, James R. Williamson, Brian K. Kennedy, Benjamin F. Cravatt, Michael Petrascheck
This study shows minocycline extends lifespan and reduces protein aggregation in old C. elegans by inhibiting translation of highly expressed mRNAs, improving proteostasis without activating stress pathways.
bioRxiv · Jul 19, 2018 · PreprintPhysiology