Author

Michael Petrascheck

The Scripps Research Institute;Primary ORCID profile (0000-0002-1010-145X · 9 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Michael PetrascheckiD9 papers · Scripps Research Institute

Biology Disciplines

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Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Organism:C. elegans· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:human· 1

Frequent Co-Authors

Alex Matthewson· 1 shared Alice L. Chen· 1 shared Anne-Laure Mahul-Mellier· 1 shared Benjamin F. CravattiD· 1 shared Brian K. Kennedy· 1 shared Carl Ash· 1 shared Caroline A. Cuoco· 1 shared Christian M. ColeiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Alex Matthewson

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2 papers

Recent·Most cited

Autophagy activator AA-20 engages CDK5 to promote lipophagy and improve neurodegeneration-associated phenotypes

Ee Phie Tan, Lydia Ambaye, Anne-Laure Mahul-Mellier, Yuting Zhang, Patricia Martinez-Botia, Sergio R. Labra, Lynee A. Massey, Zi Gao, Zainab Ahmed, Karina Nugroho, Carl Ash, Wen Ren, Christian M. Cole, Yin Wu, Sarah Ly, , Jeffery W. Kelly

AA-20 promotes lipophagy by activating lysosomal acid lipase and CDK5, reducing lipid droplet accumulation and improving neurodegeneration-associated phenotypes in cellular and organoid models.

bioRxiv · Nov 2, 2026 · PreprintMolecular Biology

Translation Attenuation by Minocycline Increases Lifespan and Improves Proteostasis in Old Post-Stress-Responsive Organisms

Gregory M. Solis, Rozina Kardakaris, Elizabeth R. Valentine, Liron Bar-Peled, Alice L. Chen, Megan M. Blewett, Mark A. McCormick, James R. Williamson, Brian K. Kennedy, Benjamin F. Cravatt, Michael Petrascheck

This study shows minocycline extends lifespan and reduces protein aggregation in old C. elegans by inhibiting translation of highly expressed mRNAs, improving proteostasis without activating stress pathways.

bioRxiv · Jul 19, 2018 · PreprintPhysiology