Author

Alicia A. Nugent

Genentech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Amber L. Cramer· 1 shared Amy W-S Leung· 1 shared Anjani Ganti· 1 shared Anna I. BakardjieviD· 1 shared Anthony A. EstradaiD· 1 shared Anton Delwig· 1 shared Audrey Gill· 1 shared Bahram Memarzadeh· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Amber L. Cramer

Mutual co-authors in cluster

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 6, 2024

SARM1 orthosteric base exchange inhibitors cause subinhibitory SARM1 activation

Rebecca Leahey, Martin Weber, Chang Hoon Cho…·Flora I. Hinz

The paper shows that subinhibitory concentrations of orthosteric SARM1 inhibitors can activate SARM1, leading to NAD consumption, neurodegeneration, and biomarker release in neurons.

9 citations

humanmouse

𝕏 PostBluesky

NeuroscienceeLifePeer-reviewedNov 14, 2023

DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress Response

Ernie Yulyaningsih, Jung H. Suh, Melania H. Fanok…·Pascal E. Sanchez

DNL343 reduces neurodegeneration in mouse models by inhibiting the integrated stress response and normalizing dysregulated biomarkers, with potential clinical relevance for vanishing white matter disease.

11 citations

mouseexperimental assay

𝕏 PostBluesky