Integrated morphological, multi-omics, and functional profiling reveals microglial plasticity driven by AD risk genes
Yingjie Zhang, Ai Zhang, Sang Seo, Craig Fredrickson, Min Jung, Xiwei Shan, Lilian Phu, Amber L. Cramer, Carlos Sánchez-Priego, Vineet Vinay Kulkarni, Christopher M. Rose, Casper C. Hoogenraad, Claire G. Jeong
This study identifies six microglial transcriptional profiles linked to specific morphological phenotypes and shows AD risk genes disrupt morpho-transcriptomic coupling and phagocytic capacity.
bioRxiv · Sep 10, 2026 · PreprintNeuroscience