Intratumoral expression of IL-12 and CD40 ligand (CD154) from plasmids generates antitumor responses that eliminate tumoral T regs
Gregory W. Ho, Alicia Santos, Jennifer L. Fields, Pamela C. Rosato, Mary Jo Turk, Nicole F. Steinmetz, Steven Fiering
This study combines IL-12 and CD154 plasmid electroporation to enhance antitumor immunity, leading to tumor clearance and reduced T regulatory cells in mouse models.
Scientific Reports · Jul 8, 2025Peer-reviewedImmunology