Mary Jo Turk

Common viral infections seed regionally distinct resident memory T cells in the human CNS

The paper identifies regionally distinct CD8+ resident memory T cells in the human CNS shaped by viral infections using single-cell RNA sequencing and T cell receptor analysis.

Circulating and brain-resident memory CD8+ T cells seed distinct bystander TRM-like populations in glioblastoma

This study identifies that circulating and brain-resident memory CD8+ T cells contribute to distinct bystander TRM-like populations in glioblastoma, with brain TRM being a major source in GBM.

Intratumoral expression of IL-12 and CD40 ligand (CD154) from plasmids generates antitumor responses that eliminate tumoral T regs

This study combines IL-12 and CD154 plasmid electroporation to enhance antitumor immunity, leading to tumor clearance and reduced T regulatory cells in mouse models.

Heterogeneity and plasticity of the naive CD4+ T cell compartment

This study identifies transcriptionally distinct naive CD4+ T cell subsets in mice and humans using scRNA-seq, showing their functional diversity and environmental responsiveness.

CD39 is expressed on functional effector and tissue resident memory CD8+ T cells

This study identifies CD39 expression on functional effector and tissue-resident memory CD8+ T cells, showing its role in memory differentiation and function, distinct from its role in T cell exhaustion.

TimiGP: inferring inter-cell functional interactions and clinical values in the tumor immune microenvironment through gene pairs

TimiGP infers functional interactions between immune cells in the tumor microenvironment and identifies their prognostic value using bulk gene expression and survival data.