Jennifer L. Fields

Effects and mechanisms of monoclonal and polyclonal human antibodies in protection of humanized mice from HIV-1 challenge

This study evaluates how monoclonal and polyclonal human antibodies protect humanized mice from HIV-1 infection, showing that both neutralization and Fc-mediated effects contribute to protection.

Intratumoral expression of IL-12 and CD40 ligand (CD154) from plasmids generates antitumor responses that eliminate tumoral T regs

This study combines IL-12 and CD154 plasmid electroporation to enhance antitumor immunity, leading to tumor clearance and reduced T regulatory cells in mouse models.