Chemogenetic Breakdown of the Dentate Gate Causes Seizures and Spatial Memory Deficits
Christopher D. Adam, Emily D. Schellinger, Alicia White, Srdjan M. Joksimovic, Hajime Takano, Douglas A. Coulter
The paper shows that increasing dentate granule cell excitability using chemogenetics causes seizures and spatial memory deficits in non-epileptic mice, supporting the dentate gate hypothesis.
bioRxiv · Nov 12, 2024 · PreprintNeuroscience