Christopher D. Adam

Disrupted Hippocampal Theta-Gamma Coupling and Spike-Field Coherence Following Experimental Traumatic Brain Injury

This study investigates changes in hippocampal oscillations after TBI, finding disrupted theta-gamma coupling and altered spike-field coherence in injured rats.

Interneuron theta phase locking controls seizure susceptibility

This study demonstrates that inhibitory theta phase locking in interneurons directly controls seizure susceptibility using a closed-loop optogenetic system.

Chemogenetic Breakdown of the Dentate Gate Causes Seizures and Spatial Memory Deficits

The paper shows that increasing dentate granule cell excitability using chemogenetics causes seizures and spatial memory deficits in non-epileptic mice, supporting the dentate gate hypothesis.

Hippocampal Interneuronal Dysfunction and Hyperexcitability in a Porcine Model of Concussion

This study examines electrophysiological changes in hippocampal neurons and their subtypes in a porcine model of concussion, finding altered properties in interneurons and hyperexcitability in pyramidal neurons.

Multichannel Silicon Probes for Awake Hippocampal Recordings in Large Animals

This study evaluates multichannel silicon probes for chronic electrophysiological recordings in large animals, finding that probe cross-sectional area and design affect single-unit performance and long-term viability.

Electrophysiological Signature Reveals Laminar Structure of the Porcine Hippocampus

The paper characterizes the laminar structure of the porcine hippocampus using histology and electrophysiology, finding features similar to both rodents and primates.