Hajime Takano

This study develops an on-demand seizure induction method in chronically epileptic mice to improve therapeutic screening for epilepsy.

This study assesses how space radiation affects cognitive circuits in male and female mice, revealing sex-specific vulnerabilities and trade-offs in neuroprotective interventions.

This study shows that retuning ventral hippocampal output in TLE mice improves social memory and reduces anxiety without suppressing seizures.

The paper shows that increasing dentate granule cell excitability using chemogenetics causes seizures and spatial memory deficits in non-epileptic mice, supporting the dentate gate hypothesis.

The paper investigates how prolonged hyperactivity in hippocampal neurons leads to persistent chloride ion accumulation in a subset of cells using imaging and statistical analysis.

This paper introduces transparent graphene microelectrodes to simultaneously record microelectrocorticography and calcium fluorescence in vivo, revealing spatiotemporal seizure dynamics through non-negative matrix factorization.