Immunization with peptide encapsulated within synthetic spores activates T cell responses and reduces tumor growth
Domenico D’Atri, Elena Tondini, Federico Machinandiarena, Minsuk Kong, Alilin Mia, Devorah L. Gallardo, Kandice Tanner, Stephen M. Hewitt, David J. FitzGerald, Kumaran S. Ramamurthi
This study shows that synthetic spore-like particles (SSHELs) enhance T cell responses and reduce tumor growth in a mouse model by efficiently delivering peptides to dendritic cells.
mBio · Sep 12, 2025Peer-reviewedCancer Biology