UV induces common cutaneous amyloid-like melanosomal protein aggregates
Nicholas Theodosakis, Porter B Howland, Miroslav Hejna, Stephen M. Ostrowski, Talya Cohen-Neamie, Remi Joseph, Helen Ji, Allison E. Greuel, Judth R. Boozer, Mariam Y. Demian, Alin Asim, Khanh Nguyen, Andrew M. Mu, Philip A. Seifert, Konrad Kaminiów, , David E. Fisher
The paper shows UV exposure causes misfolded melanosomal proteins to aggregate, contributing to skin pigmentation disorders and melanocyte dysfunction.
bioRxiv · Dec 18, 2025 · PreprintMolecular Biology