Author

Philip A. Seifert

Massachusetts Eye and Ear InfirmaryORCID 0000-0002-6951-7097Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Alexander TyshkovskiyiD· 1 shared Alin Asim· 1 shared Aline FassiniiD· 1 shared Allison E. GreueliD· 1 shared Anand K. GanesaniD· 1 shared Andrea BallabioiD· 1 shared Andrew M. MuiD· 1 shared Anna M. PuszynskaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenetics

Alexander TyshkovskiyORCID

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2 papers

Recent·Most cited

UV induces common cutaneous amyloid-like melanosomal protein aggregates

Nicholas Theodosakis, Porter B Howland, Miroslav Hejna, Stephen M. Ostrowski, Talya Cohen-Neamie, Remi Joseph, Helen Ji, Allison E. Greuel, Judth R. Boozer, Mariam Y. Demian, Alin Asim, Khanh Nguyen, Andrew M. Mu, Philip A. Seifert, Konrad Kaminiów, , David E. Fisher

The paper shows UV exposure causes misfolded melanosomal proteins to aggregate, contributing to skin pigmentation disorders and melanocyte dysfunction.

bioRxiv · Dec 18, 2025 · PreprintMolecular Biology

Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision

Yuancheng Ryan Lu, James C. Cameron, Yan Hu, Han Shen, Shintaro Shirahama, Alexander Tyshkovskiy, Zhaoyi Chen, Jiahe Ai, Daniel Y. Zhu, Margarete M. Karg, Lindsey A. Chew, George W. Bell, Siddhartha G. Jena, Yue He, Philip A. Seifert, , Jonathan S. Weissman

OSK factors rejuvenate aged RPE cells by activating a Tet2-independent oxidative resilience pathway through GSTA4, restoring vision and reversing age-related degeneration.

bioRxiv · Aug 30, 2025 · PreprintGenetics